Making a 2.5D game like Syberia can be done in 3DGS but it's kind of a pain. Read my first post in this thread to learn one technique:

http://www.coniserver.net/ubbthreads/showflat.php/Cat/0/Number/747240/

According to jcl, the engine will be given some features (see thread above) to make these types of games a bit less hassle-free, but we'll see. Of course, you can always make it completely realtime like Ankh, Sam & Max: Season 1, Culpa Innata, Bone, Dreamfall, Fahrenheit, Broken Sword 3/4, etc.

If you want an out of the box ready for 2.5D game engine, you're going to want Wintermute Engine. It's specifically designed for these kinds of games, and it's the only publically available adventure game engine that supports 3D objects. You can use Blender along with the free plugin available on their forum for the 3D graphics. You can also use Cinema4D which has a 3DS export that WME can use.

http://dead-code.org/home/

I'm making a 3rd person game like this, although it may or may not have point and click. There's a screenshot in the above thread. Please note that it is all realtime with no prerendering, and it is still work in progress. I'm currently experienting with combining a realtime 3D area with hand created/prerendered graphics like what is happening with A Vampyre Story. It gives you the detail of non-realtime but the benefits of realtime (mainly a movable camera and the realtime and/or 3D features that 3DGS has that something like Wintermute lacks) It's basically an evolved version of parallax scrolling and has been a trendy visual aesthetic esp. in the Flash animation field.

Open the link below, and click on the upper left thumbnail (it's called Underground) for an example of this technique in action (of course this is only a movie, but it's the exact same thing):

http://www.lostmarble.com/moho/gallery/musicvideos.shtml