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Right now I just set the fps_max and fps_min to 60. Any good idea?

you should use total_ticks instead of total_frames. total_frames of course isn't frame rate independent.

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i usually use something like fps_min=10 and fps_max=120 and leave time_smooth at the default value (which is 0.5). i never had big problems with those settings except if something was wrong with the script like mercuryus mentioned.