i use modo and like it a lot. it has some very nice workflow ideas. for most modeling, sculpting, texturing and rendering tasks it's a joy to use.

there also are some disadvantages though. it's one of the more buggy tools and crashes sometimes. there is no real construction history or modifier stack (for example if you extrude or clone something along a curve you can't go back later to edit the curve). you can't do character animation (yet).