You can choose different true-type fonts for the button render. Bitmap fonts are not supported at the moment.
You can set the font as bold or italic. Effects: You can set different colors for mouse off, mouse over and mouse on.
If you want to make "professional" buttons, it is of course better to create them in photoshop and load them into the tool

Do you mean to set the tool interface? No, you can't change the interface positions. If you mean the project items: Of course you can set and align them like you want, using mouse or arrow keys.

Regards
TSGames