I would suggest Silo + ZBrush (or 3D-Coat, a cheaper, but very good alternative)
Modo is very good as well, but a littel more expensive than Silo... personally i would recomment using a combination of various specific software packages over a huge all-incusive package. For example:
modelling >> Silo or Modo
topology painting >> Silo, Zbrush or 3D-Coat
uv-mapping and retopo >> 3D-Coat
exporting >> i would export to OBJ then use a cheap and proven method of reexporting through Unwrap3D, MilkShape3D or Fragmotion

The complete pipeline would cost considerably less tnah 2000$... and if you choose Silo over Modo the price drops even below 1000$

Animation is NOT included in this method (ofcourse you could animate with MilkShape or Fragmotion, but they're not the most complete solutions out there)