I am also waiting so long for a Bioforge sequel but I would also play a remake of it. At that time it was such a nice game.
The reason why Deus Ex2 and even Bioshock changed so much is easy: high production costs and main stream marketing, it is simply because of the money. A game like Bioshock, a simple RPG shooter is probably more appealing to the majority of gamers.
I would also like to see a new Outcast or a remake, why not. This was a nice game.
And I agree that we need a new game like the old Unreal. It was a nice mixture of fantasy and sci-fi, peaceful worlds combined with action fights, this was much more interesting than the Marine-missions in U2. So it really should be like the first one, maybe just a remake.
By the way I enjoyed Tomb Raider Anniversary, a remake of the old one and it is really well made.