You don't need any palette what-so-ever to work with GameStudio. The only time you would need a palette is if you were creating a game to run at 8-bit mode. As long as your game is set to 16-bit or higher then you don't need a palette.

Are you still running A5? If so, MED and WED may display in 8-bit and look aweful (depending on what driver you have set for WED) but this will not affect what the graphics look like in the running game.