Not exactly a tangible contribution, but I just learned this, and it really made me excited since I lowered my nexus size by a huge amount, and want to share with those who don't know about it...
It's about your level script and the line for max_entities. You want to make sure you have the best setting for this variable in your script!
First a partial description from SED:
max_entities
The maximum amount of entities in a level; must be set before loading of the level. The default value is NEXUS times 10.
Range:
0 .. unlimited (default: Nexus * 10)
Type:
var
Remarks:
Is to be set before level_load.
for every entity, around 1.5..2.5 KB memory is reserved from the nexus, dependent on its bones size.
Example:
max_entities = 1000; // alows up to 1000 Entities.
basically, if your max_entities is set waaaayy more than the number of entities in your level, you'r nexus will be higher than it needs to be.
This example is backwards tho... it says to set the number to 10 times the nexus... but the nexus is partly decided by the number of entities in max_entites.
-------------------
So instead,
1) Run your level, hit F11 to find out how many entities you're using.
2)In SED, set your max entities to maybe 30 more than what you have (so you can add more later if you need to).
3) Run your level again, hit F11, and see how big your nexus is.
4) In WED, under 'Map Properties' set the nexus to match the new nexus number you saw while running your level (you should round up the number)
What's the point to all this? Potentially saving memory on your custtomer's computer, enhancing performance.
I had my max_entities set at 3000 for all my levels over the past 2 years, because to me it just seemd a default number. After following the above procedure for one of my levels, my nexus size went down from 27MB to 22MB!

Now, maybe not everyone has max_entities set in their script, and maybe it's not as far off as mine was. But even so, this will help you perhaps get a bit less memory reserved to play your level. I saved 5 Megabytes!
If you do add more entities, your nexus may have to be set higher, but at least your starting as low as necessary first!
So hopefully this helps some people!
Jason