I have 2 strategies for IB API the first one assetlist include top 100 large cap stocks and I have fully updated local historic data along with my second assetlist with selected stocks such as RDN and MTG. The main problem is I cannot run both instance live which gives me error 053 and 055. I have double check if there is holiday and the correct assetlist but then only one assetlist run at a time I can switch over the two assetlists without additional issue. Any workaround to solve this?

I don't know for sure, but it's possibly an API limitation. It that's the reason, stay below the limit by reducing MaxRequests or increasing TickTime.