My experience from university is that people who are new to 3D don´t have more problems with blender than with maya, max, lightwave or whatever.

When switching from one software you are very experienced with to another one there often is a lot of cursing involved though. But this also isn´t a blender thing and usually nothing that can´t be overcome with some weeks of patience. There is no user interface standard in 3D software. All of them are very different.

You get pain from using hotkeys? Do you have some problem with your hands or something?