No, you are in trouble if you use the mouse only. Even in a text-processor I use almost only hotkeys. I use hotkeys in my programming environment. It is much faster to press F9 to compile instead to go into a menu and select one of these options there.

In a modeling software I do so many tasks again and again that I simply HAVE to shortcut. I HAVE to use keys otherwise I would need three times or even more time for the same task. I use move, rotate, scale, extrude again, again and again. It would be really dumb to not use hotkeys.

But yes, you can go into menus and call these functions via mouse-click in all these tools (including Blender). But this will take much much longer.

If you really use a tool like that then you use hotkeys automatically. If not then you are not using this tool, plain and simple.