Nope.

Hotkeys are totally cluttered and fixed. Menus are totally cluttered and fixed. No customizable toolbars, err no toolbars at all. Splitscreen? That's 19th century. You can in nowadays software open as many windows with new views as you like, and so on ...

The current UI is in fact still the first UI that is there since years. Devs prefered to throw in new tools instead doing something at the UI. And with every new bit Blender became even more cluttered, adding here a hotkey where was free space, adding there a new button where was free space ...

That now changes with 2.5. Was more than time that Blender Devs have a look for a more human UI