there are engines where it seems to be solved, using a high level abstraction so you need only to select target platform(s), only the android SDK should be installed separately, however I have no experience in it...
originally I planned development only for pc, but since tablets are getting powerful enough, I will definitely check android development possibilities in future, especially because I'm currently simplifying my game concepts, thus a much lower memory and less complex user interface would be enough... e.g. Creative Assembly is making their mobile version of Total War with Unity3D, and the current wip videos look cool. but my minister of finance prefers UE4 over Unity somehow...